Sve-trans-oktaprenil-difosfat sintaza
Sve-trans-oktaprenil-difosfat sintaza (EC 2.5.1.90, oktaprenil-difosfat sintaza, oktaprenil pirofosfat sintetaza, poliprenilpirofosfat sintetaza, terpenoidaliltransferaza, terpenil pirofosfat sintetaza, trans-heptapreniltranstransferaza, trans-preniltransferaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat:izopentenil-difosfat farneziltranstransferaza (dodaje 5 izopentenilnih jedinica).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sve-trans-oktaprenil-difosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.90 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat + 5 izopentenil difosfat 5 difosfat + sve-trans-octaprenil difosfat
Ovaj enzim katalizuje reakciju kondenzacije kojom se formira sve-trans-oktaprenil difosfat.
Reference uredi
- ↑ Fujisaki, S., Nishino, T. and Katsuki, H. (1986). „Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis”. J. Biochem. 99: 1327-1337. PMID 3519603.
- ↑ Asai, K., Fujisaki, S., Nishimura, Y., Nishino, T., Okada, K., Nakagawa, T., Kawamukai, M. and Matsuda, H. (1994). „The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase”. Biochem. Biophys. Res. Commun. 202: 340-345. PMID 8037730.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.