Sumpor nosilac protein ThiS adenililtransferaza
Sumpor nosilac protein ThiS adenililtransferaza (EC 2.7.7.73, thiF (gen)) je enzim sa sistematskim imenom ATP:(ThiS) adenililtransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sumpor nosilac protein ThiS adenililtransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.7.73 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + [ThiS] difosfat + adenilil-[ThiS]
Ovaj enzim vezuje jon Zn2+.
Reference
uredi- ↑ Taylor, S.V., Kelleher, N.L., Kinsland, C., Chiu, H.J., Costello, C.A., Backstrom, A.D., McLafferty, F.W. and Begley, T.P. (1998). „Thiamin biosynthesis in Escherichia coli. Identification of this thiocarboxylate as the immediate sulfur donor in the thiazole formation”. J. Biol. Chem. 273: 16555-16560. PMID 9632726.
- ↑ Xi, J., Ge, Y., Kinsland, C., McLafferty, F.W. and Begley, T.P. (2001). „Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex”. Proc. Natl. Acad. Sci. USA 98: 8513-8518. PMID 11438688.
- ↑ Duda, D.M., Walden, H., Sfondouris, J. and Schulman, B.A. (2005). „Structural analysis of Escherichia coli ThiF”. J. Mol. Biol. 349: 774-786. PMID 15896804.
- ↑ Lehmann, C., Begley, T.P. and Ealick, S.E. (2006). „Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis”. Biochemistry 45: 11-19. PMID 16388576.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.