Sterol 24-C-metiltransferaza
Sterol 24-C-metiltransferaza (EC 2.1.1.41, Delta24-metiltransferaza, Delta24-sterol metiltransferaza, zimosterol-24-metiltransferaza, S-adenozil-4-metionin:sterol Delta24-metiltransferaza, SMT1, 24-sterol C-metiltransferaza, S-adenozil-L-metionin:Delta24(23)-sterol metiltransferaza, fitosterol metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:zimosterol 24-C-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sterol 24-C-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.41 | ||||||||
| CAS broj | 37257-07-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + 5alfa-holesta-8,24-dien-3beta-ol S-adenozil-L-homocistein + 24-metilin-5alfa-holest-8-en-3beta-ol
Za dejstvo ovog enzima je neophodan glutation. On deluje na opseg sterola sa 24(25)-dvostrukom vezom u bočnom lancu.
Reference uredi
- ↑ Moore, J.T., Jr. and Gaylor, J.L. (1969). „Isolation and purification of an S-adenosylmethionine: Δ24-sterol methyltransferase from yeast”. J. Biol. Chem. 244: 6334-6340. PMID 5354959.
- ↑ Venkatramesh, M., Guo, D., Jia, Z. and Nes, W.D. (1996). „Mechanism and structural requirements for transformations of substrates by the S-adenosyl-L-methionine:Δ24(25)-sterol methyl transferase enzyme from Saccharomyces cerevisiae”. Biochim. Biophys. Acta 1299: 313-324. PMID 8597586.
- ↑ Tong, Y., McCourt, B.S., Guo, D., Mangla, A.T., Zhou, W.X., Jenkins, M.D., Zhou, W., Lopez, M. and Nes, W.D. (1997). „, Stereochemical features of C-methylation on the path to Δ24(28)-methylene and Δ24(28)-ethylidene sterols: studies on the recombinant phytosterol methyl transferase from Arabidopsis thaliana”. Tetrahedron Lett. 38: 6115-6118.
- ↑ Bouvier-Navé, P., Husselstein, T. and Benveniste, P. (1998). „Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant biosynthesis”. Eur. J. Biochem. 256: 88-96. PMID 9746350.
- ↑ Nes, W.D., McCourt, B.S., Zhou, W., Ma, J., Marshall, J.A., Peek, L.A. and Brennan, M. (1998). „Overexpression, purification, and stereochemical studies of the recombinant S-adenosyl-L-methionine:Δ24(25)- to Δ24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae sterol methyl transferase”. Arch. Biochem. Biophys. 353: 297-311. PMID 9606964.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.