Spermidin sintaza
Spermidin sintaza (EC 2.5.1.16, aminopropiltransferaza, putrescinska aminopropiltransferaza, spermidinska sintetaza, SpeE) je enzim sa sistematskim imenom S-adenozilmetioninamin:putrescin 3-aminopropiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Spermidin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Tetramer spermidin sintaze (Bacillus subtilis) | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.5.1.16 | ||||||||
| CAS broj | 37277-82-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozilmetioninamin + putrescin 5'-S-metil-5'-tioadenozin + spermidin
Ovaj enzim nije identičan sa EC 2.5.1.22, sperminskom sintazom. Enzim sisara je visoko specifičan, dok bakterijski enzim može da koristi druge akceptore i može da sintetizuje spermin.
Reference uredi
- ↑ Hannonen, P., Janne, J. and Raina, A. (1972). „Partial purification and characterization of spermine synthase from rat brain”. Biochim. Biophys. Acta 289: 225-231. PMID 4564056.
- ↑ Pegg, A.E., Shuttleworth, K. and Hibasami, H. (1981). „Specificity of mammalian spermidine synthase and spermine synthase”. Biochem. J. 197: 315-320. PMID 6798961.
- ↑ Tabor, C.W. (1962). „Propylamine transferase (spermidine synthesis)”. Methods Enzymol. 5: 761-765.
- ↑ Tabor, H. and Tabor, C.W. (1972). „Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 203-268. PMID 4628436.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.