Skvalen—hopenska ciklaza
Skvalen—hopenska ciklaza (EC 5.4.99.17, Squalene—hopene cyclase) je enzim sa sistematskim imenom skvalen mutaza (ciklizacija, formira hop-22(29)-en).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Skvalen—hopenska ciklaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.17 | ||||||||
| CAS broj | 76600-69-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- skvalen hop-22(29)-en
Ovaj enzim takođe formira ciklizacioni produk hopan-22-ol.
Reference uredi
- ↑ Hoshino, T. and Sato, T. (2002). „Squalene-hopene cyclase: catalytic mechanism and substrate recognition”. Chem. Commun.: 291-301. PMID 12120044.
- ↑ Hoshino, T., Nakano, S., Kondo, T., Sato, T. and Miyoshi, A. (2004). „Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring”. Org Biomol Chem 2: 1456-1470. PMID 15136801.
- ↑ Sato, T., Kouda, M. and Hoshino, T. (2004). „Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius”. Biosci. Biotechnol. Biochem. 68: 728-738. PMID 15056909.
- ↑ Reinert, D.J., Balliano, G. and Schulz, G.E. (2004). „Conversion of squalene to the pentacarbocyclic hopene”. Chem. Biol. 11: 121-126. PMID 15113001.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.