Serin 3-dehidrogenaza
Serin 3-dehidrogenaza (EC 1.1.1.276, serinska 3-dehidrogenaza) je enzim sa sistematskim imenom L-serin:NADP+ 3-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Serin 3-dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.276 | ||||||||
| CAS broj | 9038-55-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-serin + NADP+ 2-amoniomalonat semialdehid + NADPH + H+
Product, 2-amonomalonat semialdehid, se spontano konvertuje u 2-aminoacetaldehid i CO2. NAD+ ne može da zameni NADP+.
Reference uredi
- ↑ Fujisawa, H., Nagata, S., Chowdhury, E.K., Matsumoto, M. and Misono, H. (2002). „Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens”. Biosci. Biotechnol. Biochem. 66: 1137-1139. PMID 12092831.
- ↑ Chowdhury, E.K., Higuchi, K., Nagata, S. and Misono, H. (1997). „A novel NADP+ dependent serine dehydrogenase from Agrobacterium tumefaciens”. Biosci. Biotechnol. Biochem. 61: 152-157. PMID 9028042.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.