Sekologanin sintaza
Sekologanin sintaza (EC 1.3.3.9, sekologaninska sintaza) je enzim sa sistematskim imenom loganin:kiseonik oksidoreduktaza (otvaranje prstena).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Sekologanin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.3.9 | ||||||||
| CAS broj | 258339-71-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- loganin + NADPH + H+ + O2 sekologanin + NADP+ + 2H2O
Ovaj enzim je hem-tiolatni protein (P-450). Sekologanin je prekurzor monoterpenoidnih indolnih alkaloida.
Reference uredi
- ↑ Yamamoto, H., Katano, N., Ooi, A. and Inoue, K. (2000). „Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P-450”. Phytochemistry 53: 7-12. PMID 10656401.
- ↑ Irmler, S., Schroder, G., St-Pierre, B., Crouch, N.P., Hotze, M., Schmidt, J., Strack, D., Matern, U. and Schroder, J. (2000). „Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P-450 CYP72A1 as secologanin synthase”. Plant J. 24: 797-804. PMID 11135113.
- ↑ Yamamoto, H., Katano, N., Ooi, Y. and Inoue, K. (1999). „Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures”. Phytochemistry 50: 417-422.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.