Scitalonska dehidrataza
Scitalonska dehidrataza (EC 4.2.1.94, scitalonska 7,8-hidrolijaza) je enzim sa sistematskim imenom scitalon 7,8-hidrolijaza (formira 1,3,8-trihidroksinaftalen).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Scitalonska dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.94 | ||||||||
| CAS broj | 118901-79-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- scitalon 1,3,8-trihidroksinaftalen + H2O
Ovaj enzim zajedno sa enzimom EC 1.1.1.252, tetrahidroksinaftalenskom reduktazom, učestvuje u biosintezi melanina u patogenim gljivama.
Reference
uredi- ↑ Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A. (1988). „Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi”. Exp. Mycol. 12: 367-376.
- ↑ Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J. (1989). „Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus”. Exp. Mycol. 13: 69-69.
- ↑ Wheeler, M.H. and Greenblatt, G.A. (1988). „The inhibition of melanin biosynthetic reactions in Pyricularia oryzae' by compounds that prevent rice blast disease”. Exp. Mycol. 12: 151-160.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.