Salicilat 1-monooksigenaza
Salicilat 1-monooksigenaza (EC 1.14.13.1, salicilatna hidroksilaza, salicilatna 1-hidroksilaza, salicilatna monooksigenaza, salicilatna hidroksilaza (dekarboksilacija)) je enzim sa sistematskim imenom salicilat,NADH:kiseonik oksidoreduktaza (1-hidroksilacija, dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Salicilat 1-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.1 | ||||||||
| CAS broj | 9059-28-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim je flavoprotein (FAD).
Reference
uredi- ↑ Suzuki, K., Takemori, S. and Katagiri, M. (1969). „Mechanism of the salicylate hydroxylase reaction. IV. Fluorimetric analysis of the complex formation”. Biochim. Biophys. Acta 191: 77-85. PMID 4390441.
- ↑ Takemori, S., Yasuda, H., Mihara, K., Suzuki, K. and Katagiri, M. (1969). „Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex”. Biochim. Biophys. Acta 191: 58-68. PMID 4898626.
- ↑ Takemori, S., Yasuda, H., Mihara, K., Suzuki, K. and Katagiri, M. (1969). „Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin”. Biochim. Biophys. Acta 191: 69-76. PMID 4309912.
- ↑ Yamamoto, S., Katagiri, M., Maeno, H. and Hayaishi, O. (1965). „Salicylate hydroxylase, a monooxygenase requiring flavin adenine dinucleotide”. J. Biol. Chem. 240: 3408-3413. PMID 14321380.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.