Matriptaza
(Preusmjereno sa stranice ST14)
Matriptaza (EC 3.4.21.109, serinska proteaza 14, membranski-tip serinske proteaza 1, MT-SP1, prostamin, serinska proteaza TADG-15, diferencijalno izraženi protein gena 15 asociran sa tumorom, ST14, proteaza raka dojke 80 kDa, epitin, serinska endopeptidaza SNC19) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Matriptaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.109 | ||||||||
| CAS broj | 241475-96-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Presecanje raznih sintetičkih supstrata sa Arg ili Lys u P1 poziciji i sa preferencijom za aminokiseline sa malim bočnim lancima (Ala i Gly) u P2 poziciji
Ova tripsin-slična integralno-membranska serinska peptidaza učestvuje u razvoju i metastazi raka dojke.
Reference uredi
- ↑ Lee, S.L., Dickson, R.B. and Lin, C.Y. (2000). „Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease”. J. Biol. Chem. 275: 36720-36725. PMID 10962009.
- ↑ Lin, C.Y., Anders, J., Johnson, M., Sang, Q.A. and Dickson, R.B. (1999). „Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity”. J. Biol. Chem. 274: 18231-18236. PMID 10373424.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.