Spermin oksidaza
(Preusmjereno sa stranice SMO/PAOh1)
Spermin oksidaza (EC 1.5.3.16, PAOh1/SMO, PAOh1 (nespecifična), AtPAO1, AtPAO4, SMO, mSMO, SMO(PAOh1), SMO/PAOh1, SMO5, mSMOmu) je enzim sa sistematskim imenom spermidin:kiseonik oksidoreduktaza (formira spermidin).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Spermin oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.3.16 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- spermin + O2 + H2O spermidin + 3-aminopropanal +H2O2
Ovaj enzim iz Arabidopsis thaliana (AtPAO1) oksiduje norspermin do norspermidin sa visokom efikasnošću.
Reference uredi
- ↑ Murray-Stewart, T., Wang, Y., Goodwin, A., Hacker, A., Meeker, A. and Casero, R.A., Jr. (2008). „Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology”. FEBS J. 275: 2795-2806. PMID 18422650.
- ↑ Cervelli, M., Polticelli, F., Federico, R. and Mariottini, P. (2003). „Heterologous expression and characterization of mouse spermine oxidase”. J. Biol. Chem. 278: 5271-5276. PMID 12458219.
- ↑ Tavladoraki, P., Rossi, M.N., Saccuti, G., Perez-Amador, M.A., Polticelli, F., Angelini, R. and Federico, R. (2006). „Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion”. Plant Physiol. 141: 1519-1532. PMID 16778015.
- ↑ Wang, Y., Murray-Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P.M. and Casero, R.A., Jr. (2003). „Properties of purified recombinant human polyamine oxidase, PAOh1/SMO”. Biochem. Biophys. Res. Commun. 304: 605-611. PMID 12727196.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.