Sfingomijelinska deacilaza
(Preusmjereno sa stranice SM-GCer deacylase)
Sfingomijelinska deacilaza (EC 3.5.1.109, SM deacilaza, GcSM deacilaza, glukozilkeramid sfingomijelinska deacilaza, sfingomijelin glukozilkeramidna deacilaza, SM glukozilkeramid GCer deacilaza, SM-GCer deacilaza, SMGCer deacilaza) je enzim sa sistematskim imenom N-acil-sfingozilfosforilholin amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sfingomijelinska deacilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.109 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) N-acil-sfingozilfosforilholin + H2O masna kiselina + sfingozilfosforilholin;;
- (2) D-glukozil-N-acilsfingozin + H2O masna kiselina + D-glukozil-sfingozin
Ovaj enzim učestvuje u sfingolipidnom metabolizmu u epidermisu.
Reference
uredi- ↑ Hara, J., Higuchi, K., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis”. J. Invest. Dermatol. 115: 406-413. PMID 10951276.
- ↑ Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. and Imokawa, G. (2000). „The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide”. Biochem. J. 350: 747-756. PMID 10970788.
- ↑ Ishibashi, M., Arikawa, J., Okamoto, R., Kawashima, M., Takagi, Y., Ohguchi, K. and Imokawa, G. (2003). „Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis”. Lab. Invest. 83: 397-408. PMID 12649340.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.