Epi-izozizaenska sintaza
(Preusmjereno sa stranice SCO5222 protein)
Epi-izozizaenska sintaza (EC 4.2.3.37, SCO5222 protein) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-epi-isozizaen).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Epi-izozizaenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.37 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat (+)-epi-isozizaen + difosfat
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference uredi
- ↑ Lin, X., Hopson, R. and Cane, D.E. (2006). „Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase”. J. Am. Chem. Soc. 128: 6022-6023. PMID 16669656.
- ↑ Zhao, B., Lin, X., Lei, L., Lamb, D.C., Kelly, S.L., Waterman, M.R. and Cane, D.E. (2008). „Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)”. J. Biol. Chem. 283: 8183-8189. PMID 18234666.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.