S1PR4

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Sfingozin 1-fosfatni receptor 4 (S1PR4) je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P). Gen S1PR4 ne sadrži introne.

Sfingozin 1-fosfat receptor 4
Dostupne strukture
2DCO
Identifikatori
Simboli	S1PR4; EDG6; LPC1; S1P4; SLP4
Vanjski ID	OMIM: 603751 MGI: 1333809 HomoloGene: 2799 IUPHAR: S1P4 GeneCards: S1PR4 Gene
Ontologija gena Molekularna funkcija • aktivnost G-protein spregnutog receptora • aktivnost faktora guanil-nukleotidne razmene • vezivanje masne kiseline Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • metabolički proces energetske rezerve • signalni put G-protein spregnutog receptora • pozitivna regulacija kalcijumskog jonskog transporta u citozol
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	8698	13611
Ensembl	ENSG00000125910	ENSMUSG00000044199
UniProt	O95977	Q9Z0L1
RefSeq (mRNA)	NM_003775.3	NM_010102.2
RefSeq (protein)	NP_003766.1	NP_034232.1
Lokacija (UCSC)	Chr 19: 3.18 - 3.18 Mb	Chr 10: 80.96 - 80.96 Mb
PubMed pretraga	[1]	[2]

Funkcija

Ovaj protein učestvuje u endotelnoj diferencijaciji. Za njega se vezuju lizofosfolipidi ili lizosfingolipidi. On učestvuje u ćelijskoj signalizaciji mnogih ćelijskih tipova. Specifičan ze za limfoidna tkiva.

Literatura

• Gräler MH, Bernhardt G, Lipp M (1998). „EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.”. Genomics 53 (2): 164–9. DOI:10.1006/geno.1998.5491. PMID 9790765. 
• Yamazaki Y, Kon J, Sato K, et al. (2000). „Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.”. Biochem. Biophys. Res. Commun. 268 (2): 583–9. DOI:10.1006/bbrc.2000.2162. PMID 10679247. 
• Van Brocklyn JR, Gräler MH, Bernhardt G, et al. (2000). „Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.”. Blood 95 (8): 2624–9. PMID 10753843. 
• Idzko M, Panther E, Corinti S, et al. (2002). „Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.”. Faseb J. 16 (6): 625–7. PMID 11919175. 
• Kveberg L, Bryceson Y, Inngjerdingen M, et al. (2002). „Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.”. Eur. J. Immunol. 32 (7): 1856–64. DOI:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604. 
• Candelore MR, Wright MJ, Tota LM, et al. (2002). „Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.”. Biochem. Biophys. Res. Commun. 297 (3): 600–6. DOI:10.1016/S0006-291X(02)02237-4. PMID 12270137. 
• Contos JJ, Ye X, Sah VP, Chun J (2002). „Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.”. FEBS Lett. 531 (1): 99–102. DOI:10.1016/S0014-5793(02)03409-9. PMID 12401211. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Vogler R, Sauer B, Kim DS, et al. (2003). „Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.”. J. Invest. Dermatol. 120 (4): 693–700. DOI:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. 
• Gräler MH, Grosse R, Kusch A, et al. (2003). „The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13.”. J. Cell. Biochem. 89 (3): 507–19. DOI:10.1002/jcb.10537. PMID 12761884. 
• Kyi CS, Key SJ, Lloyd TW (2003). „Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm.”. International journal of oral and maxillofacial surgery 32 (3): 337–8. DOI:10.1054/ijom.2003.0364. PMID 12767884. 
• Holdsworth G, Osborne DA, Pham TT, et al. (2005). „A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.”. BMC Biochem. 5: 12. DOI:10.1186/1471-2091-5-12. PMID 15298705. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 

Spoljašnje veze

• „Lysophospholipid Receptors: S₁P₄”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
• MeSH Lysophospholipid+receptors

Vidi još

• Lizofosfolipidni receptor