(Fruktoza-bisfosfat aldolaza)-lizin N-metiltransferaza
(Preusmjereno sa stranice S-adenozil-L-metionin:(3-phospho-D-glycerate-carboxy-lyase (dimerizing))-lysine 6-N-methyltransferase)
(Fruktoza-bisfosfat aldolaza)-lizin N-metiltransferaza (EC 2.1.1.259, rubisko metiltransferaza, ribuloza-bisfosfat-karboksilaza/oksigenaza N-metiltransferaza, ribuloza-1,5-bisfosfat karboksilaza/oksigenaza velike podjedinice epsilon N-metiltransferaza, S-adenozil-L-metionin:(3-fosfo-D-glicerat-karboksi-lijaza (dimerizacija))-lizin 6-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:(fruktoza-bisfosfat aldolaza)-lizin N6-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
(Fruktoza-bisfosfat aldolaza)-lizin N-metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.259 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 3 S-adenozil-L-metionin + [fruktoza-bisfosfat aldolaza]-L-lizin 3 S-adenozil-L-homocistein + [fruktoza-bisfosfat aldolaza]-N6,N6,N6-trimetil-L-lizin
Ovaj enzim metiliše konzervirani lizin u C-terminalom delu fruktoza-bisfosfatne aldolaze (EC 4.1.2.13) viših biljaka.
Reference
uredi- ↑ Magnani, R., Nayak, N.R., Mazarei, M., Dirk, L.M. and Houtz, R.L. (2007). „Polypeptide substrate specificity of PsLSMT. A set domain protein methyltransferase”. J. Biol. Chem. 282: 27857-27864. PMID 17635932.
- ↑ Mininno, M., Brugiere, S., Pautre, V., Gilgen, A., Ma, S., Ferro, M., Tardif, M., Alban, C. and Ravanel, S. (2012). „Characterization of chloroplastic fructose 1,6-bisphosphate aldolases as lysine-methylated proteins in plants”. J. Biol. Chem. 287: 21034-21044. PMID 22547063.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.