Hidroksiacilglutationska hidrolaza
(Preusmjereno sa stranice S-(2-hidroksiacil)glutation hidrolaza)
Hidroksiacilglutationska hidrolaza (EC 3.1.2.6, glioksalaza II, S-2-hidroksilacilglutationska hidrolaza, acetoacetilglutationska hidrolaza) je enzim sa sistematskim imenom S-(2-hidroksiacil)glutation hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hidroksiacilglutationska hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.2.6 | ||||||||
| CAS broj | 9025-90-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-(2-hidroksiacil)glutation + H2O glutation + 2-hidroksi karboksilat
Ovaj enzim takođe u manjoj meri hidrolizuje S-acetoacetilglutation.
Reference
uredi- ↑ Racker, E. (1952). „Spectrophotometric measurements of the metabolic formation and degradation of thiol esters and enediol compounds”. Biochim. Biophys. Acta 9: 577-579. PMID 13032160.
- ↑ Uotila, L. (1973). „Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases”. Biochemistry 12: 3938-3943. PMID 4200890.
- ↑ Uotila, L. (1973). „Purification and characterization of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from human liver”. Biochemistry 12: 3944-3951. PMID 4745654.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.