Rozmarinat sintaza
Rozmarinat sintaza (EC 2.3.1.140, rozmarinsko kiselinska sintaza, kafeoil-koenzim A:3,4-dihidroksifenilmlečna kiselina kafeoiltransferaza, 4-kumaroil-KoA:4-hidroksifenilmlečna kiselina 4-kumaroil transferaza) je enzim sa sistematskim imenom kafeoil-KoA:3-(3,4-dihidroksifenil)laktat 2'-O-kafeoil-transferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Rozmarinat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.140 | ||||||||
| CAS broj | 117590-80-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- kafeoil-KoA + 3-(3,4-dihidroksifenil)laktat KoA + rosmarinat
Ovaj enzim učestvuje zajedno sa EC 1.1.1.237 (hidroksifenilpiruvat reduktazom) u biosintezi rozmarinske kiseline.
Reference
uredi- ↑ Petersen, M. and Alfermann, A.W. (1988). „Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase”. Z. Naturforsch. C: Biosci. 43: 501-504.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.