Ribonukleozid-trifosfat reduktaza
Ribonukleozid-trifosfat reduktaza (EC 1.17.4.2, ribonukleotidna reduktaza, 2'-dezoksiribonukleozid-trifosfat:oksidovani-tioredoksin 2'-oksidoreduktaza) je enzim sa sistematskim imenom 2'-dezoksiribonukleozid-trifosfat:tioredoksin-disulfid 2'-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Ribonukleozid-trifosfat reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 1.17.4.2 | ||||||||
| CAS broj | 9068-66-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2'-dezoksiribonukleozid trifosfat + tioredoksin disulfid + H2O ribonukleozid trifosfat + tioredoksin
Za rad ovog enzima je neophodan kobamidni koenzim i ATP.
Reference
uredi- ↑ Blakley, R.L. (1965). „Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii”. J. Biol. Chem. 240: 2173-2180. PMID 14299643.
- ↑ Goulian, M. and Beck, W.S. (1966). „Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii”. J. Biol. Chem. 241: 4233-4242. PMID 5924645.
- ↑ Lammers, M. and Follmann, H. (1983). „The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation”. Struct. Bonding 54: 27-91.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.