Retikulin oksidaza

Retikulin oksidaza (EC 1.21.3.3, BBE, berberinski-most enzim, enzim formiranja berberinskog mosta, tetrahidroprotoberberinska sintaza) je enzim sa sistematskim imenom (S)-retikulin:kiseonik oksidoreduktaza (formira metilinski most).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Retikulin oksidaza
Identifikatori
EC broj 1.21.3.3
CAS broj 152232-28-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
(S)-retikulin + O2 (S)-skoulerin + H2O2

Ovaj enzim sadrži FAD. Enzim iz biljke Eschscholtzia californica kovalentno vezuje kofaktor.

Reference uredi

  1. Steffens, P., Nagakura, N. and Zenk, M.H. (1984). „The berberine bridge forming enzyme in tetrahydroprotoberberine biosynthesis”. Tetrahedron Lett. 25: 951-952. 
  2. Dittrich, H. and Kutchan, T.M. (1991). „Molecular cloning, expression and induction of the berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack”. Proc. Natl. Acad. Sci. USA 88: 9969-9973. PMID 1946465. 
  3. Kutchan, T.M. and Dittrich, H. (1995). „Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in higher plants”. J. Biol. Chem. 270: 24475-24481. PMID 7592663. 

Literatura uredi

Spoljašnje veze uredi