Citrat (Re)-sintaza
(Preusmjereno sa stranice Re-citratna sintaza)
Citrat (Re)-sintaza (EC 2.3.3.3, (R)-citratna sintaza, Re-citratna sintaza, citrat oksaloacetatna lijaza ((pro-3R)-CH2COO--acetil-KoA)) je enzim sa sistematskim imenom acetil-KoA:oksaloacetat C-acetiltransferaza (tioestarska hidroliza, formiranje (pro-R)-karboksimetila).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Citrat (Re)-sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.3.3 | ||||||||
| CAS broj | 9077-70-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + H2O + oksaloacetat citrat + KoA
Ovaj enzim se inaktivira kiseonikom. On je prisutan kod pojedinih anaeroba.
Reference
uredi- ↑ Dittbrenner, S., Chowdhury, A.A. and Gottschalk, G. (1969). „The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate”. Biochem. Biophys. Res. Commun. 36: 802-808. PMID 5808294.
- ↑ Gottschalk, G. (1969). „Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici”. Eur. J. Biochem. 7: 301-306. PMID 4974734.
- ↑ Gottschalk, G. and Barker, H.A. (1966). „Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase”. Biochemistry 5: 1125-1133. PMID 5958189.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.