Kalicivirin
(Preusmjereno sa stranice Rabbit hemorrhagic disease virus 3C endopeptidase)
Kalicivirin (EC 3.4.22.66, Camberwell virus procesujuća peptidaza, Chiba virus procesujuća peptidaza, Norwalk virus procesujuća peptidaza, Southampton virus procesujuća peptidaza, norovirus virus procesujuća peptidaza, calicivirus tripsinu-slična cisteinska proteaza, calicivirus TCP, calicivirus 3C-slična proteaza, calicivirus endopeptidaza, 3C endopeptidaza virusa bolesti zečje bolesti krvarenja) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Kalicivirin | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.22.66 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Endopeptidaza sa a preference for cleavage when the P1 pozicija is occupied by Glu- and the P1' pozicija is occupied by Gly-
Virusi koji su članovi Norovirusnog roda (Caliciviridae familije) su glavni uzrok epidemijskog akutnog viralnog gastroenteritisa.
Reference uredi
- ↑ Meyers, G., Rossi, C. and Thiel, H.J. (2004). „Calicivirus endopeptidases”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1380-1382.
- ↑ Wirblich, C., Sibilia, M., Boniotti, M.B., Rossi, C., Thiel, H.J. and Meyers, G. (1995). „3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity”. J. Virol. 69: 7159-7168. PMID 7474137.
- ↑ Martín Alonso, J.M., Casais, R., Boga, J.A. and Parra, F. (1996). „Processing of rabbit hemorrhagic disease virus polyprotein”. J. Virol. 70: 1261-1265. PMID 8551592.
- ↑ Liu, B., Clarke, I.N. and Lambden, P.R. (1996). „Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis”. J. Virol. 70: 2605-2610. PMID 8642693.
- ↑ Liu, B.L., Viljoen, G.J., Clarke, I.N. and Lambden, P.R. (1999). „Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli”. J. Gen. Virol. 80: 291-296. PMID 10073687.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Meyers, G., Rossi, C. and Thiel, H.J. (2004). „Calicivirus endopeptidases”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1380-1382.