Ruselizin
(Preusmjereno sa stranice RVV-V)
Ruselizin (EC 3.4.24.58, Russell's viper venomni faktor X aktivator, RVV-X, krvno-koagulacioni faktor X aktivacioni enzim, metaloproteinaza RVV-x, Vipera russelli proteinaza, Russell's viper krvno koagulacioni faktor X activator, RVV-V) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ruselizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.58 | ||||||||
| CAS broj | 79393-92-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Specifično aktivira nekoliko komponenti sistema zgrušavanja krvi, uključujući koagulacioni faktor X, koagulacioni faktor IX i protein C putem razlaganja -Arg- veza. Ne deluje na insulinski B lanac
Ovaj enzim je prisutanu venumu zmije Vipera russelli.
Reference uredi
- ↑ Furie, B.C. and Furie, B. (1976). „Coagulant protein of Russell's viper venom”. Methods Enzymol. 45: 191-205. PMID 1011991.
- ↑ Lindquist, P.A., Fujikawa, K. and Davie, E.W. (1978). „Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecent) and a protease from Russell's viper venom”. J. Biol. Chem. 253: 1902-1909. PMID 632245.
- ↑ Takeya, H., Nishida, S., Miyata, T., Kawada, S., Saisaka, Y., Morita, T. and Iwanaga, S. (1992). „Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains”. J. Biol. Chem. 267: 14109-14117. PMID 1629211.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.