Sve-trans-retinil-palmitatna hidrolaza
(Preusmjereno sa stranice RPE65 (gen))
Sve-trans-retinil-palmitatna hidrolaza (EC 3.1.1.64, sve-trans-retinil-palmitat hidrolaza, sve-trans-retinol izomeraza:hidrolaza, sve-trans-retinilestar 11-cis izomerohidrolaza, RPE65 (gen)) je enzim sa sistematskim imenom sve-trans-retinil estar acilhidrolaza, formira 11-cis retinol.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sve-trans-retinil-palmitatna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.64 | ||||||||
| CAS broj | 106389-24-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- sve-trans-retinil estar + H2O 11-cis-retinol + masna kiselina
Ovaj enzim, koji deluje u retinalnom pigmentnom epitelu (RPE), katalizuje razlaganje i izomerizaciju sve-trans-retinil masno kiselinskih estara do 11-cis-retinola.
Reference uredi
- ↑ Blaner, W.S., Das, S.R., Gouras, P. and Flood, M.T. (1987). „Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells”. J. Biol. Chem. 262: 53-58. PMID 3793734.
- ↑ Bernstein, P.S., Law, W.C. and Rando, R.R. (1987). „Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro”. Proc. Natl. Acad. Sci. USA 84: 1849-1853. PMID 3494246.
- ↑ Bridges, C.D. and Alvarez, R.A. (1987). „The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium”. Science 236: 1678-1680. PMID 3603006.
- ↑ Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B.X. and Ma, J.X. (2005). „RPE65 is the isomerohydrolase in the retinoid visual cycle”. Proc. Natl. Acad. Sci. USA 102: 12413-12418. PMID 16116091.
- ↑ Nikolaeva, O., Takahashi, Y., Moiseyev, G. and Ma, J.X. (2009). „Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane”. FEBS J. 276: 3020-3030. PMID 19490105.
- ↑ Golczak, M., Kiser, P.D., Lodowski, D.T., Maeda, A. and Palczewski, K. (2010). „Importance of membrane structural integrity for RPE65 retinoid isomerization activity”. J. Biol. Chem. 285: 9667-9682. PMID 20100834.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.