RNK-usmerena RNK polimeraza
RNK-usmerena RNK polimeraza (EC 2.7.7.48, RNK nukleotidiltransferaza (RNK-zavisna), RNK-zavisna ribonukleatna nukleotidiltransferaza, 3D polimeraza, PB1 proteini, PB2 proteini, fag f2 replikaza, polimeraza L, Q-beta replikaza, fag f2 replikaza, ribonukleinsko kiselinska replikaza, ribonukleat nukleotidiltransferaza zavisna od ribonukleinske kiseline, ribonukleinsko kiselinskaa polimeraza zavisna od ribonukleinske kiseline, ribonukleinska replikaza, ribonukleinska sintetaza, RNK replikaza, RNK sintetaza, RNK transkriptaza, RNK-zavisna ribonukleatna nukleotidiltransferaza, RDRP, RNK-zavisna RNK polimeraza, RNK-zavisna RNK replikaza, transkriptaza) je enzim sa sistematskim imenom nukleozid-trifosfat:RNK nukleotidiltransferaza (RNK-zavisna).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| RNK-usmerena RNK polimeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| RNK-usmerena RNK polimeraza, Cypovirus | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.7.48 | ||||||||
| CAS broj | 9026-28-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- nukleozid trifosfat + RNKn difosfat + RNKn+1
Ovaj enzim katalizuje RNK-šablnom usmereno produženje 3'- kraja RNK lanaca, dodajući jedan po jedan nukleotid.
Reference uredi
- ↑ August, J.T., Cooper, S., Shapiro, L. and Zinder, N.D. (1963). „RNA phage induced RNA polymerase”. Cold Spring Harbour Symp. Quant. Biol. 28: 95-97.
- ↑ Haruna, J., Nozu, K., Ohtaka, Y. and Spiegelman, S. (1963). „A'n RNA "Replicase" induced by and selective for a viral RNA: isolation and properties”. Proc. Natl. Acad. Sci. USA 50: 905-911.
- ↑ Weismann, C., Simon, L. and Ochoa, S. (1963). „Induction by an RNA phage of an enzyme catalyzing incorporation of ribonucleotides into ribonucleic acid”. Proc. Natl. Acad. Sci. USA 49: 407-414.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.