RGS17
(Preusmjereno sa stranice RGSZ2)
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Regulator G proteinske signalizacije 17 (RGS17) je protein koji je kod čoveka kodiran RGS17 genom.[1][2]
| Regulator G proteinske signalizacije 17 | |||||||||||
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 PDB prikaz baziran na 1zv4. | |||||||||||
| Dostupne strukture | |||||||||||
| 1zv4 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | RGS17; RGS-17; RGSZ2; hRGS17 | ||||||||||
| Vanjski ID | OMIM: 607191 MGI: 1927469 HomoloGene: 8242 GeneCards: RGS17 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 26575 | 56533 | |||||||||
| Ensembl | ENSG00000091844 | ENSMUSG00000019775 | |||||||||
| UniProt | Q9UGC6 | Q6P208 | |||||||||
| RefSeq (mRNA) | NM_012419 | NM_019958 | |||||||||
| RefSeq (protein) | NP_036551 | NP_064342 | |||||||||
| Lokacija (UCSC) | Chr 6: 153.37 - 153.49 Mb | Chr 10: 4.42 - 4.51 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Ovaj gen kodira člana regulatorne G-proteinske signalne familije. Ovaj protein sadrži konzervirani motiv od 120 aminokiselina koji se naziva RGS domen, i cisteinom bogati region. On prigušuje signalnu aktivnost G-proteina vezivanjem za aktiviranu, GTP-vezanu G alfa podjedinicu i delujući kao aktivirajući protein GTPaze (GAP), čime povišava brzinu GTP konverzije do GDP-a. Ova hidroliza omogućava G alfa podjedinicama da se vežu za G beta/gama heterodimere, formirajući neaktivne G-proteinske heterotrimere, čime se zaustavlja signal.[2] Zajedno sa RGS4, RGS9 i RGS14,[3][4] RGS17 učestvuje u terminaciji signalizacije mi opioidnog receptora i razvoju tolerancije na opioidne analgetike.[5][6]
Reference
uredi- ↑ Jordan JD, Carey KD, Stork PJ, Iyengar R (Aug 1999). „Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein”. J Biol Chem 274 (31): 21507–10. DOI:10.1074/jbc.274.31.21507. PMID 10419452.
- ↑ 2,0 2,1 „Entrez Gene: RGS17 regulator of G-protein signalling 17”.
- ↑ Garzón J, Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P (June 2005). „Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS”. Psychopharmacology 180 (1): 1–11. DOI:10.1007/s00213-005-2248-9. PMID 15830230.
- ↑ Rodríguez-Muñoz M, de la Torre-Madrid E, Gaitán G, Sánchez-Blázquez P, Garzón J (December 2007). „RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons”. Cellular Signalling 19 (12): 2558–71. DOI:10.1016/j.cellsig.2007.08.003. PMID 17825524.
- ↑ Garzón J, Rodríguez-Muñoz M, López-Fando A, Sánchez-Blázquez P (September 2005). „The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins”. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 30 (9): 1632–48. DOI:10.1038/sj.npp.1300726. PMID 15827571.
- ↑ Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P, Garzón J (2007). „Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins”. Molecular Pain 3: 19. DOI:10.1186/1744-8069-3-19. PMC 1947952. PMID 17634133.
Literatura
uredi- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mao H, Zhao Q, Daigle M, et al. (2004). „RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling.”. J. Biol. Chem. 279 (25): 26314–22. DOI:10.1074/jbc.M401800200. PMID 15096504.
- Larminie C, Murdock P, Walhin JP, et al. (2004). „Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.”. Brain Res. Mol. Brain Res. 122 (1): 24–34. DOI:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Fischer T, De Vries L, Meerloo T, Farquhar MG (2003). „Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.”. Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8270–5. DOI:10.1073/pnas.1432965100. PMC 166218. PMID 12826607.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sierra DA, Gilbert DJ, Householder D, et al. (2002). „Evolution of the regulators of G-protein signaling multigene family in mouse and human.”. Genomics 79 (2): 177–85. DOI:10.1006/geno.2002.6693. PMID 11829488.