RGS8

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Regulator G-proteinske signalizacije 8 je protein koji je kod ljudi kodiran RGS8 genom.

Regulator G-proteinske signalizacije 8
PDB prikaz baziran na 2ihd.
Dostupne strukture
2IHD, 2ODE
Identifikatori
Simboli	RGS8; MGC119067; MGC119068; MGC119069
Vanjski ID	OMIM: 607189 HomoloGene: 23152 GeneCards: RGS8 Gene
Ontologija gena Molekulska funkcija • aktivnost GTPaznog aktivatora Ćelijska komponenta • citoplazma • ćelijska membrana Biološki proces • terminacija signalnog puta G-protein spregnutog receptora • pozitivna regulacija GTPazne aktivnosti
Ortolozi
Vrsta	Čovek	Miš
Entrez	85397	67792
Ensembl	ENSG00000135824	ENSMUSG00000042671
UniProt	P57771	Q8BXT1
Ref. Sekv. (iRNK)	NM_001102450	NM_026380
Ref. Sekv. (protein)	NP_001095920	NP_080656
Lokacija (UCSC)	Chr 1: 182.62 - 182.65 Mb	Chr 1: 153.65 - 153.7 Mb
PubMed pretraga	[1]	[2]

Ovaj gen je član familje regulatora G proteinske signalizacije (RGS). On kodira protein sa jednim RGS domenom. Regulatori G proteinske signalizacije (RGS) su regulatorne i strukturne komponente G protein spregnutih receptorskih kompleksa. Oni ubrzavaju prenos kroz ciklus GTP vezivanja i hidrolize do GDP, čime završavaju prenos signala, mada paradoksalno, isto tako ubrzavaju receptorom stimulisanu aktivaciju.

Literatura

• Berman DM, Wilkie TM, Gilman AG (1996). „GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits”. Cell 86 (3): 445–452. DOI:10.1016/S0092-8674(00)80117-8. PMID 8756726. 
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). „Creation of genome-wide protein expression libraries using random activation of gene expression.”. Nat. Biotechnol. 19 (5): 440–5. DOI:10.1038/88107. PMID 11329013. 
• Luo X, Popov S, Bera AK, Wilkie TM, Muallem S (2001). „RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations”. Molecular Cell 7 (3): 651-660. DOI:10.1016/S1097-2765(01)00211-8. PMID 11463389. 
• Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (2011). „Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner”. J Biol Chem 286 (17): 15116-15125. DOI:10.1074/jbc.M110.216234. PMID 21357625. 
• Popov S, Yu K, Kozasa T, Wilkie TM (1997). „The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro”. Proc Natl Acad Sci USA 94 (14): 7216-20. DOI:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071. 
• Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). „Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity”. J Biol Chem 275 (25): 18962-8. DOI:10.1074/jbc.M001128200. PMID 10747990. 
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• Masuho I, Itoh M, Itoh H, Saitoh O (2004). „The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression.”. J. Neurochem. 88 (1): 161–8. DOI:10.1046/j.1471-4159.2003.02139.x. PMID 14675160. 
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• Benians A, Nobles M, Hosny S, Tinker A (2005). „Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.”. J. Biol. Chem. 280 (14): 13383–94. DOI:10.1074/jbc.M410163200. PMID 15677457. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414. 
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• Wilkie TM, Kinch L (2005). „New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart”. Current Biology 15 (20): R843-54. DOI:10.1016/j.cub.2005.10.008. PMID 16243026.