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RAD51

(Preusmjereno sa stranice RECA)
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RAD51 je eukariotski gen. Protein kodiran ovim genom je član RAD51 proteinske familije koja pomaže u popravci dvolančanih prekida DNK. Članovi RAD51 familije su homologni sa bakterijkim RecA i kvaščanim Rad51. Ovaj protein je visoko konzerviran kod većine eukariota, od kvasca do ljudi.

RAD51 homolog (S. cerevisiae)

Rad51 filament baziran na 1SZP.[1]
Dostupne strukture
1B22, 1N0W
Identifikatori
SimboliRAD51; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA
Vanjski IDOMIM: 179617 MGI: 97890 HomoloGene: 2155 GeneCards: RAD51 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez588819361
EnsemblENSG00000051180ENSMUSG00000027323
UniProtQ06609Q08297
RefSeq (mRNA)NM_001164269.1NM_011234.4
RefSeq (protein)NP_001157741.1NP_035364.1
Lokacija (UCSC)Chr 15:
40.99 - 41.02 Mb		Chr 2:
118.94 - 118.97 Mb
PubMed pretraga[1][2]

Varijante uredi

Dve alternativno splajsovane transkriptne varijante ovog gena, koje kodiraju zasebne proteina, su poznate. Transkriptne varijante koje koriste alternativne polyA signale postoje.

Interakcije uredi

RAD51 možed da formira interakcije sa BRE,[2] RAD54B,[3] Serinska proteinska kinaza ATM,[4] BRCC3,[2] BARD1,[2] BRCA2,[2][5][6][7][8][9][10][11][12][13][14][15][16] UBE2I,[17][18] Abl gen,[4] BRCA1,[2][15][19][20] ATRX,[3][21] RAD52,[4] DMC1,[22] P53[2][23][24] i Protein Blumovog sindroma.[25]

Reference uredi

  1. ↑ Conway AB, Lynch TW, Zhang Y, Fortin GS, Fung CW, Symington LS, Rice PA. (2004). „Crystal structure of a Rad51 filament”. Nat Struct Mol Biol 11 (8): 791–6. PMID 15235592. 
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 Dong, Yuanshu; Hakimi Mohamed-Ali, Chen Xiaowei, Kumaraswamy Easwari, Cooch Neil S, Godwin Andrew K, Shiekhattar Ramin (November 2003). „Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair”. Mol. Cell (United States) 12 (5): 1087–99. DOI:10.1016/S1097-2765(03)00424-6. ISSN 1097-2765. PMID 14636569. 
  3. ↑ 3,0 3,1 Tanaka, K; Hiramoto T, Fukuda T, Miyagawa K (August 2000). „A novel human rad54 homologue, Rad54B, associates with Rad51”. J. Biol. Chem. (UNITED STATES) 275 (34): 26316–21. DOI:10.1074/jbc.M910306199. ISSN 0021-9258. PMID 10851248. 
  4. ↑ 4,0 4,1 4,2 Chen, G; Yuan S S, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff S P, Wu Y, Arlinghaus R, Baltimore D, Gasser P J, Park M S, Sung P, Lee E Y (April 1999). „Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl”. J. Biol. Chem. (UNITED STATES) 274 (18): 12748–52. DOI:10.1074/jbc.274.18.12748. ISSN 0021-9258. PMID 10212258. 
  5. ↑ Sharan, S K; Morimatsu M, Albrecht U, Lim D S, Regel E, Dinh C, Sands A, Eichele G, Hasty P, Bradley A (April 1997). „Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2”. Nature (ENGLAND) 386 (6627): 804–10. DOI:10.1038/386804a0. ISSN 0028-0836. PMID 9126738. 
  6. ↑ Lin, Horng-Ru; Ting Nicholas S Y, Qin Jun, Lee Wen-Hwa (September 2003). „M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex”. J. Biol. Chem. (United States) 278 (38): 35979–87. DOI:10.1074/jbc.M210659200. ISSN 0021-9258. PMID 12815053. 
  7. ↑ Yu, David S; Sonoda Eiichiro, Takeda Shunichi, Huang Christopher L H, Pellegrini Luca, Blundell Tom L, Venkitaraman Ashok R (October 2003). „Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2”. Mol. Cell (United States) 12 (4): 1029–41. DOI:10.1016/S1097-2765(03)00394-0. ISSN 1097-2765. PMID 14580352. 
  8. ↑ Chen, P L; Chen C F, Chen Y, Xiao J, Sharp Z D, Lee W H (April 1998). „The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (9): 5287–92. DOI:10.1073/pnas.95.9.5287. ISSN 0027-8424. PMC 20253. PMID 9560268. 
  9. ↑ Sarkisian, C J; Master S R, Huber L J, Ha S I, Chodosh L A (October 2001). „Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals”. J. Biol. Chem. (United States) 276 (40): 37640–8. DOI:10.1074/jbc.M106281200. ISSN 0021-9258. PMID 11477095. 
  10. ↑ Wong, A K; Pero R, Ormonde P A, Tavtigian S V, Bartel P L (December 1997). „RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2”. J. Biol. Chem. (UNITED STATES) 272 (51): 31941–4. DOI:10.1074/jbc.272.51.31941. ISSN 0021-9258. PMID 9405383. 
  11. ↑ Katagiri, T; Saito H, Shinohara A, Ogawa H, Kamada N, Nakamura Y, Miki Y (March 1998). „Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51”. Genes Chromosomes Cancer (UNITED STATES) 21 (3): 217–22. DOI:10.1002/(SICI)1098-2264(199803)21:3<217::AID-GCC5>3.0.CO;2-2. ISSN 1045-2257. PMID 9523196. 
  12. ↑ Pellegrini, Luca; Yu David S, Lo Thomas, Anand Shubha, Lee MiYoung, Blundell Tom L, Venkitaraman Ashok R (November 2002). „Insights into DNA recombination from the structure of a RAD51-BRCA2 complex”. Nature (England) 420 (6913): 287–93. DOI:10.1038/nature01230. ISSN 0028-0836. PMID 12442171. 
  13. ↑ Tarsounas, Madalena; Davies Adelina A, West Stephen C (January 2004). „RAD51 localization and activation following DNA damage”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (England) 359 (1441): 87–93. DOI:10.1098/rstb.2003.1368. ISSN 0962-8436. PMC 1693300. PMID 15065660. 
  14. ↑ Liu, J; Yuan Y, Huan J, Shen Z (January 2001). „Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2”. Oncogene (England) 20 (3): 336–45. DOI:10.1038/sj.onc.1204098. ISSN 0950-9232. PMID 11313963. 
  15. ↑ 15,0 15,1 Chen, J; Silver D P, Walpita D, Cantor S B, Gazdar A F, Tomlinson G, Couch F J, Weber B L, Ashley T, Livingston D M, Scully R (September 1998). „Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells”. Mol. Cell (UNITED STATES) 2 (3): 317–28. DOI:10.1016/S1097-2765(00)80276-2. ISSN 1097-2765. PMID 9774970. 
  16. ↑ Marmorstein, L Y; Ouchi T, Aaronson S A (November 1998). „The BRCA2 gene product functionally interacts with p53 and RAD51”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (23): 13869–74. DOI:10.1073/pnas.95.23.13869. ISSN 0027-8424. PMC 24938. PMID 9811893. 
  17. ↑ Kovalenko, O V; Plug A W, Haaf T, Gonda D K, Ashley T, Ward D C, Radding C M, Golub E I (April 1996). „Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (7): 2958–63. DOI:10.1073/pnas.93.7.2958. ISSN 0027-8424. PMC 39742. PMID 8610150. 
  18. ↑ Shen, Z; Pardington-Purtymun P E, Comeaux J C, Moyzis R K, Chen D J (October 1996). „Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system”. Genomics (UNITED STATES) 37 (2): 183–6. DOI:10.1006/geno.1996.0540. ISSN 0888-7543. PMID 8921390. 
  19. ↑ Scully, R; Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston D M (January 1997). „Association of BRCA1 with Rad51 in mitotic and meiotic cells”. Cell (UNITED STATES) 88 (2): 265–75. DOI:10.1016/S0092-8674(00)81847-4. ISSN 0092-8674. PMID 9008167. 
  20. ↑ Wang, Q; Zhang H, Guerrette S, Chen J, Mazurek A, Wilson T, Slupianek A, Skorski T, Fishel R, Greene M I (August 2001). „Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1”. Oncogene (England) 20 (34): 4640–9. DOI:10.1038/sj.onc.1204625. ISSN 0950-9232. PMID 11498787. 
  21. ↑ Sigurdsson, Stefan; Van Komen Stephen, Petukhova Galina, Sung Patrick (November 2002). „Homologous DNA pairing by human recombination factors Rad51 and Rad54”. J. Biol. Chem. (United States) 277 (45): 42790–4. DOI:10.1074/jbc.M208004200. ISSN 0021-9258. PMID 12205100. 
  22. ↑ Masson, J Y; Davies A A, Hajibagheri N, Van Dyck E, Benson F E, Stasiak A Z, Stasiak A, West S C (November 1999). „The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51”. EMBO J. (ENGLAND) 18 (22): 6552–60. DOI:10.1093/emboj/18.22.6552. ISSN 0261-4189. PMC 1171718. PMID 10562567. 
  23. ↑ Stürzbecher, H W; Donzelmann B, Henning W, Knippschild U, Buchhop S (April 1996). „p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction”. EMBO J. (ENGLAND) 15 (8): 1992–2002. ISSN 0261-4189. PMC 450118. PMID 8617246. 
  24. ↑ Buchhop, S; Gibson M K, Wang X W, Wagner P, Stürzbecher H W, Harris C C (October 1997). „Interaction of p53 with the human Rad51 protein”. Nucleic Acids Res. (ENGLAND) 25 (19): 3868–74. DOI:10.1093/nar/25.19.3868. ISSN 0305-1048. PMC 146972. PMID 9380510. 
  25. ↑ Wu, L; Davies S L, Levitt N C, Hickson I D (June 2001). „Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51”. J. Biol. Chem. (United States) 276 (22): 19375–81. DOI:10.1074/jbc.M009471200. ISSN 0021-9258. PMID 11278509. 

Spoljašnje veze uredi

Izvor: https://sh.wikipedia.org/w/index.php?title=RAD51&oldid=15584143