11-cis-retinol dehidrogenaza
(Preusmjereno sa stranice RDH5 (gene name))
11-Cis-retinol dehidrogenaza (EC 1.1.1.315, RDH5 (gen)) je enzim sa sistematskim imenom 11-cis-retinol:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 11-cis-retinol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.315 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 11-cis-retinol---[retinal-vezujući-protein] + NAD+ 11-cis-retinal---[retinol-vezujući-protein] + NADH + H+
Ovaj enzim, izobilno prisutan u retinalnom pigmentnom epitelijumu, katalizuje redukciju 11-cis-retinola do 11-cis-retinala, dok je supstrat vezan za retinal-vezujući protein. To je presudni korak u regeneraciji 11-cis-retinala, hromofora rodopsina. Ovaj enzim takođe može da deluje na druge cis forme retinola.
Reference
uredi- ↑ Simon, A., Hellman, U., Wernstedt, C. and Eriksson, U. (1995). „The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases”. J. Biol. Chem. 270: 1107-1112. PMID 7836368.
- ↑ Wang, J., Chai, X., Eriksson, U. and Napoli, J.L. (1999). „Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue”. Biochem. J. 338: 23-27. PMID 9931293.
- ↑ Liden, M., Romert, A., Tryggvason, K., Persson, B. and Eriksson, U. (2001). „Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus”. J. Biol. Chem. 276: 49251-49257. PMID 11675386.
- ↑ Wu, Z., Yang, Y., Shaw, N., Bhattacharya, S., Yan, L., West, K., Roth, K., Noy, N., Qin, J. and Crabb, J.W. (2003). „Mapping the ligand binding pocket in the cellular retinaldehyde binding protein”. J. Biol. Chem. 278: 12390-12396. PMID 12536149.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.