Pteridin reduktaza
Pteridin reduktaza (EC 1.5.1.33, PTR1, pteridinska reduktaza 1) je enzim sa sistematskim imenom 5,6,7,8-tetrahidrobiopterin:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pteridin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.1.33 | ||||||||
| CAS broj | 131384-61-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 5,6,7,8-tetrahidrobiopterin + 2 NADP+ biopterin + 2 NADPH + 2 H+
Ovaj enzim iz Leishmania katalizuje redukciju posredstvom NADPH. On deluje na folat i znatan broj drugih nekonjugovanih pterina, uključujući biopterin, do njihovih tetrahidro formi. On takođe katalizuje redukciju 7,8-dihidropterina i 7,8-dihidrofolata do njihovih tetrahidro formi.
Reference uredi
- ↑ Nare, B., Hardy, L. and Beverley, S.M. (1997). „The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major”. J. Biol. Chem. 272: 13883-13891. PMID 9153248.
- ↑ Gourley, D.G., Schüttelkopf, A.W., Leonard, G.A., Luba, J., Hardy, L.W., Beverley, S.M. and Hunter, W.N. (2001). „Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites”. Nat. Struct. Biol. 8: 521-525. PMID 11373620.
- ↑ Fitzpatrick, P.F. (2000). „The aromatic amino acid hydroxylases”. Adv. Enzymol. Relat. Areas Mol. Biol. 74: 235-294. PMID 10800597.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.