Pseudouridilatna sintaza
(Preusmjereno sa stranice Pseudouridilatna sintetaza)
Pseudouridilatna sintaza (EC 4.2.1.70, pseudouridilno kiselinska sintetaza, pseudouridin monofosfatna sintetaza, 5-riboziluracil 5-fosfatna sintetaza, pseudouridilatna sintetaza, upsilonUMP sintetaza, uracilna hidrolijaza (dodaje D-riboza 5-fosfat)) je enzim sa sistematskim imenom uracil hidrolijaza (dodaje D-riboza 5-fosfat, formira pseudouridin-5'-fosfat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pseudouridilatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.70 | ||||||||
| CAS broj | 9023-35-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- uracil + D-riboza 5-fosfat pseudouridin 5'-fosfat + H2O
Reference uredi
- ↑ Heinrikson, R.L. and Goldwasser, E. (1964). „Studies on the biosynthesis of 5-ribosyluracil 5′-monophosphate in Tetrahymena pyriformis”. J. Biol. Chem. 239: 1177-1187. PMID 14165924.
- ↑ Matsushita, T. and Davis, F.F. (1971). „Studies on pseudouridylic acid synthetase from various sources”. Biochim. Biophys. Acta 238: 165-173. PMID 4936431.
- ↑ Rensen, J.F., Matsushita, T., Chirikjian, J.G. and Davis, F.F. (1972). „Enzymatic synthesis of deoxypseudouridylic acid and a study of certain of its properties”. Biochim. Biophys. Acta 281: 481-487. PMID 4569284.
- ↑ Suzuki, T. and Hochater, R.M. (1966). „On the biosynthesis of pseudouridine and of pseudouridylic acid in Agrobacterium tumefaciens”. Can. J. Biochem. 44: 259-272. PMID 5942965.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.