Protein ksiloziltransferaza
Protein ksiloziltransferaza (EC 2.4.2.26, UDP-D-ksiloza:protein osnove beta-D-ksiloziltransferaze, UDP-D-ksiloza:protein osnove ksiloziltransferaze, UDP-D-ksiloza:proteoglikan proteina osnove beta-D-ksiloziltransferaze, UDP-ksiloza-protein osnove beta-D-ksiloziltransferaze, uridin difosfoksiloza-protein osnove beta-ksiloziltransferaze, uridin difosfoksiloza-protein ksiloziltransferaza) je enzim sa sistematskim imenom UDP-D-ksiloza:protein beta-D-ksiloziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Protein ksiloziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.26 | ||||||||
| CAS broj | 55576-38-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Prenosi beta-D-ksilozilni ostatak sa UDP-D-ksiloze na serinsku hidroksi grupu akceptora proteinskog supstrata
Ovaj enzim učestvuje u biosintezi vezivnog regiona glikozaminoglikanskih lanaca tokom biosinteze proteoglikana (hondroitina, dermatana i heparan sulfata).
Reference
uredi- ↑ Stoolmiller, A.C., Horwitz, A.L. and Dorfman, A. (1972). „Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase”. J. Biol. Chem. 247: 3525-3532. PMID 5030630.
- ↑ Götting, C., Kuhn, J., Zahn, R., Brinkmann, T. and Kleesiek, K. (2000). „Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein β-D-xylosyltransferase and its first isoform XT-II”. J. Mol. Biol. 304: 517-528. PMID 11099377.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.