Prepilinska peptidaza
Prepilinska peptidaza (EC 3.4.23.43) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Prepilinska peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.43 | ||||||||
| CAS broj | 202833-59-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Tipično dolazi do razlaganja -Gly-Phe- veze čime se oslobađa N-terminalni, bazni peptid sa 5-8 ostataka sa tipa IV prepilina, i zatim se N-metiliše nova N-terminal amino grupa, pri čemu je metilni donor S-adenozil-L-metionin
Ovaj enzim je prisutan u mnogim vrstama bakterije Carry pili.
Reference
uredi- ↑ Lory, S. and Strom, M.S. (1997). „Structure-function relationship of type-IV prepilin peptidase of Pseudomonas aeruginosa - A review”. Gene 192: 117-121. PMID 9224881.
- ↑ LaPointe, C.F. and Taylor, R.K. (2000). „The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases”. J. Biol. Chem. 275: 1502-1510. PMID 10625704.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.