Preflagelinska peptidaza
Preflagelinska peptidaza (EC 3.4.23.52, FlaK) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Preflagelinska peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.52 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Odvaja signalni peptid sa 3 do 12 aminokiselina sa N-terminala preflagelina, obično na Arg-Gly- ili Lys-Gly-, čime se oslobađa flagelin.
Ovaj enzim je aspartička peptidaza iz Acrhaea.
Reference
uredi- ↑ Bardy, S.L. and Jarrell, K.F. (2002). „FlaK of the archaeon Methanococcus maripaludis possesses preflagellin peptidase activity”. FEMS Microbiol. Lett. 208: 53-59. PMID 11934494.
- ↑ Ng, S.Y., VanDyke, D.J., Chaban, B., Wu, J., Nosaka, Y., Aizawa, S. and Jarrell, K.F. (2009). „Different minimal signal peptide lengths recognized by the archaeal prepilin-like peptidases FlaK and PibD”. J. Bacteriol. 191: 6732-6740. PMID 19717585.
- ↑ Hu, J., Xue, Y., Lee, S. and Ha, Y. (2011). „The crystal structure of GXGD membrane protease FlaK”. Nature 475: 528-531. PMID 21765428.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.