Prefenatna dehidrataza
Prefenatna dehidrataza (EC 4.2.1.51, prefenatna hidrolijaza (dekarboksilacija)) je enzim sa sistematskim imenom prefenat hidrolijaza (dekarboksilacija; formira fenilpiruvat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Prefenatna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Prefenatna dehidrataza homotetramer, Paenarthrobacter aurescens | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.1.51 | ||||||||
| CAS broj | 9044-88-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- prefenat fenilpiruvat + H2O + CO2
Bakterijski enzim takođe deluje kao horizmat mutaza (EC 5.4.99.5).
Reference uredi
- ↑ Cerutti, P. and Guroff, G. (1965). „Enzymatic formation of phenylpyruvic acid in Pseudomonas sp. (ATCC 11299A) and its regulation”. J. Biol. Chem. 240: 3034-3048. PMID 14342329.
- ↑ Cotton, R.G.H. and Gibson, F. (1965). „The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase”. Biochim. Biophys. Acta 100: 76-88. PMID 14323651.
- ↑ Schmidt, J.C. and Zalkin, H. (1969). „Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium”. Biochemistry 8: 174-181.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.