Precorin-3B sintaza
Precorin-3B sintaza (EC 1.14.13.83, prekorin-3X sintaza, CobG) je enzim sa sistematskim imenom prekorin-3A,NADH:kiseonik oksidoreduktaza (20-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Precorin-3B sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.83 | ||||||||
| CAS broj | 152787-63-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- prekorin-3A + NADH + H+ + O2 prekorin-3B + NAD+ + H2O
Ovaj enzim je gvožđe-sumporni protein. Kiseonični atom se inkorporira u makrociklus na C-20.
Reference uredi
- ↑ Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F. (1993). „Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans”. J. Bacteriol. 175: 7430-7440. PMID 8226690.
- ↑ Scott, A.I., Roessner, C.A., Stolowich, N.J., Spencer, J.B., Min, C. and Ozaki, S.I. (1993). „Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group”. FEBS Lett. 331: 105-108. PMID 8405386.
- ↑ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390-412. PMID 12195810.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.