Poliamin oksidaza (formira propan-1,3-diamin)
Poliamin oksidaza (formira propan-1,3-diamin) (EC 1.5.3.14, MPAO, kukuruzna PAO) je enzim sa sistematskim imenom spermidin:kiseonik oksidoreduktaza (formira propan-1,3-diamin).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Poliamin oksidaza (formira propan-1,3-diamin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.3.14 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- spermidin + O2 +H2O propan-1,3-diamin + 4-aminobutanal +H2O2
Produkti ove reakcija se ne mogu direktno konvertovati u druge poliamine, te se smatra da ova klasa oksidaza učestvuje u terminalnom katabolizami poliamina.
Reference uredi
- ↑ Tavladoraki, P., Schinina, M.E., Cecconi, F., Di Agostino, S., Manera, F., Rea, G., Mariottini, P., Federico, R. and Angelini, R. (1998). „Maize polyamine oxidase: primary structure from protein and cDNA sequencing”. FEBS Lett. 426: 62-66. PMID 9598979.
- ↑ Federico, R., Ercolini, L., Laurenzi, M., Angelini, R. (1996). „Oxidation of acetylpolyamines by maize polyamine oxidase”. Phytochemistry 43: 339-341.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.