Piruvat dehidrogenaza (NADP+)
Piruvat dehidrogenaza (NADP+) (EC 1.2.1.51, piruvatna dehidrogenaza (NADP+)) je enzim sa sistematskim imenom piruvat:NADP+ 2-oksidoreduktaza (KoA-acetilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Piruvat dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.51 | ||||||||
| CAS broj | 93389-35-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- piruvat + KoA + NADP+ acetil-KoA + CO2 + NADPH
Ovaj evglenski enzim takođe može da koristi FAD ili metil viologen kao akceptor, mada to snižava brzinu dejstva enzima. Dejstvo ovog enzima inhira kiseonik.
Reference uredi
- ↑ Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S. Occurrence of oxygen-sensitive, NADP (1984). „+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis”. J. Biochem. (Tokyo) 96: 931-934. PMID 6438078.
- ↑ Inui, H., Ono, K., Miyatake, K., Nakano, Y. and Kitaoka, S. (1987). „Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis”. J. Biol. Chem. 262: 9130-9135. PMID 3110154.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.