Pirolizin—tRNKPil ligaza
Pirolizin—tRNKPil ligaza (EC 6.1.1.26, PylS, pirolizil-tRNK sintetaza) je enzim sa sistematskim imenom L-pirrolizin:tRNKPil ligaza (formira AMP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pirolizin—tRNKPil ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.1.1.26 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
U organizmima kao što je metanosarcina barkeri koji inkorporiraju modifikovanu aminokiselinu pirolizin (Pyl) u pojedine metilaminske metiltransferaze, jedana neobična tRNKPyl, sa CUA antikodonom, može direktno da veže pirolizin posredstvom ove klase II aminoacil-tRNK ligaza.
Reference
uredi- ↑ Blight, S.K., Larue, R.C., Mahapatra, A., Longstaff, D.G., Chang, E., Zhao, G., Kang, P.T., Green-Church, K.B., Chan, M.K. and Krzycki, J.A. (2004). „Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo”. Nature 431: 333-335. PMID 15329732.
- ↑ Polycarpo, C., Ambrogelly, A., Bérubé, A., Winbush, S.M., McCloskey, J.A., Crain, P.F., Wood, J.L. and Söll, D. (2004). „An aminoacyl-tRNA synthetase that specifically activates pyrrolysine”. Proc. Natl. Acad. Sci. USA 101: 12450-12454. PMID 15314242.
- ↑ Schimmel, P. and Beebe, K. (2004). „Molecular biology: genetic code seizes pyrrolysine”. Nature 431: 257-258. PMID 15372017.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.