Peptidilna-glutamatna 4-karboksilaza
Peptidilna-glutamatna 4-karboksilaza (EC 4.1.1.90, vitamin K-zavisna karboksilaza, gama-glutamil karboksilaza) je enzim sa sistematskim imenom peptidil-glutamat 4-karboksilaza (2-metil-3-fitil-1,4-naftohinon-epoksidacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Peptidilna-glutamatna 4-karboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.1.90 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- peptidil-4-karboksiglutamat + 2,3-epoksifilohinon + H2O peptidil-glutamat + CO2 + O2 + filohinon
Ovaj enzim može da koristi razne derivate vitamina K, uključujući menahinon.
Reference uredi
- ↑ Dowd, P., Hershline, R., Ham, S.W. and Naganathan, S. (1995). „Vitamin K and energy transduction: a base strength amplification mechanism”. Science 269: 1684-1691. PMID 7569894.
- ↑ Furie, B., Bouchard, B.A. and Furie, B.C. (1999). „Vitamin K-dependent biosynthesis of γ-carboxyglutamic acid”. Blood 93: 1798-1808. PMID 10068650.
- ↑ Rishavy, M.A., Hallgren, K.W., Yakubenko, A.V., Shtofman, R.L., Runge, K.W. and Berkner, K.L. (2006). „Bronsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation”. Biochemistry 45: 13239-13248. PMID 17073445.
- ↑ Silva, P.J. and Ramos, M.J. (2007). „Reaction mechanism of the vitamin K-dependent glutamate carboxylase: a computational study”. J. Phys. Chem. B 111: 12883-12887. PMID 17935315.
- ↑ Decottignies-Le Maréchal, P., Ducrocq, C., Marquet, A. and Azerad, R. (1984). „The stereochemistry of hydrogen abstraction in vitamin K-dependent carboxylation”. J. Biol. Chem. 259: 15010-15012. PMID 6150930.
- ↑ Dubois, J., Dugave, C., Foures, C., Kaminsky, M., Tabet, J.C., Bory, S., Gaudry, M. and Marquet, A. (1991). „Vitamin K dependent carboxylation: determination of the stereochemical course using 4-fluoroglutamyl-containing substrate”. Biochemistry 30: 10506-10512. PMID 1931973.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.