Pentalenenska sintaza
Pentalenenska sintaza (EC 4.2.3.7, pentalenenska sintetaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira pentalenen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pentalenenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.7 | ||||||||
| CAS broj | 90597-46-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat pentalenen + difosfat
Ovaj enzim je prisutan u Streptomyces avermitilis.
Reference uredi
- ↑ Cane, D.E. (1983). „Cell-free studies of monoterpene and sesquiterpene biosynthesis”. Biochem. Soc. Trans. 11: 510-515. PMID 6642060.
- ↑ Cane, D.E. and Tillman, A.M. (1983). „Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate”. J. Am. Chem. Soc. 105: 122-124.
- ↑ Cane, D.E., Sohng, J.K., Lamberson, C.R., Rudnicki, S.M., Wu, Z., Lloyd, M.D., Oliver, J.S. and Hubbard, B.R. (1994). „Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319”. Biochemistry 33: 5846-5857. PMID 8180213.
- ↑ Cane, D.E., Abell, C., Harrison, P.H., Hubbard, B.R., Kane, C.T., Lattman, R., Oliver, J.S. and Weiner, S.W. (1991). „Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions”. Philos. Trans. R. Soc. Lond. B Biol. Sci. 332: 123-129. PMID 1678531.
- ↑ Lesburg, C.A., Zhai, G., Cane, D.E. and Christianson, D.W. (1997). „Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology”. Science 277: 1820-1824. PMID 9295272.
- ↑ Zu, L., Xu, M., Lodewyk, M.W., Cane, D.E., Peters, R.J. and Tantillo, D.J. (2012). „Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry”. J. Am. Chem. Soc. 134: 11369-11371. PMID 22738258.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.