Aminodezoksihorizmat sintaza
(Preusmjereno sa stranice PabB)
Aminodezoksihorizmat sintaza (EC 2.6.1.85, ADC sintaza, 4-amino-4-dezoksihorizmatna sintaza, PabB, horizmat:L-glutamin amido-ligaza) je enzim sa sistematskim imenom horizmat:L-glutamin aminotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aminodezoksihorizmat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.85 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim se sastoji od dva dela, PabA i PabB. U odsustvu PabA i glutamina, PabB konvertuje amonijak i horizmat u 4-amino-4-dezoksihorizmat (u prisustvu Mg2+). PabA konvertuje glutamin u glutamat samo kad je prisutna stohiometrijka količina PabB. Ovaj enzim se spreže sa EC 4.1.3.38, aminodezoksihorizmatnom lijazom, da formira 4-aminobenzoat.
Reference uredi
- ↑ Ye, Q.Z., Liu, J. and Walsh, C.T. (1990). „p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase”. Proc. Natl. Acad. Sci. USA 87: 9391-9395. PMID 2251281.
- ↑ Viswanathan, V.K., Green, J.M. and Nichols, B.P. (1995). „Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli”. J. Bacteriol. 177: 5918-5923. PMID 7592344.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.