Fenilacetil-KoA 1,2-epoksidaza
(Preusmjereno sa stranice PaaABC(D)E)
Fenilacetil-KoA 1,2-epoksidaza (EC 1.14.13.149, ring 1,2-fenilacetil-KoA epoksidaza, fenilacetil-KoA monooksigenaza, PaaAC, PaaABC(D)E) je enzim sa sistematskim imenom fenilacetil-KoA:kiseonik oksidoreduktaza (1,2-epoksidacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fenilacetil-KoA 1,2-epoksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.149 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- fenilacetil-KoA + NADPH + H+ + O2 2-(1,2-epoksi-1,2-dihidrofenil)acetil-KoA + NADP+ + H2O
Ovaj enzim učestvuje u aerobnom katabolizmu fenilacetata kod Escherichia coli i Pseudomonas putida.
Reference uredi
- ↑ Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. (2010). „Bacterial phenylalanine and phenylacetate catabolic pathway revealed”. Proc. Natl. Acad. Sci. USA 107: 14390-14395. PMID 20660314.
- ↑ Grishin, A.M., Ajamian, E., Zhang, L. and Cygler, M. (2010). „Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66: 1045-1049. PMID 20823522.
- ↑ Grishin, A.M., Ajamian, E., Tao, L., Zhang, L., Menard, R. and Cygler, M. (2011). „Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex”. J. Biol. Chem. 286: 10735-10743. PMID 21247899.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.