Inozin monofosfatna sintaza
(Preusmjereno sa stranice PURH)
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Bifunkcionalni purinski biosintetički protein PURH je protein koji je kod čoveka kodiran ATIC genom.[1][2][3]
| 5-Aminoimidazol-4-karboksamid ribonukleotid formiltransferaza/IMP ciklohidrolaza | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 1p4r | |||||||||||
| Dostupne strukture | |||||||||||
| 1P4R, 1PKX, 1PL0 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | ATIC; AICAR; AICARFT; IMPCHASE; PURH | ||||||||||
| Vanjski ID | OMIM: 601731 MGI: 1351352 HomoloGene: 2983 GeneCards: ATIC Gene | ||||||||||
| EC broj | 3.5.4.10 2.1.2.3, 3.5.4.10 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 471 | 108147 | |||||||||
| Ensembl | ENSG00000138363 | ENSMUSG00000026192 | |||||||||
| UniProt | P31939 | Q9CWJ9 | |||||||||
| RefSeq (mRNA) | NM_004044 | NM_026195 | |||||||||
| RefSeq (protein) | NP_004035 | NP_080471 | |||||||||
| Lokacija (UCSC) | Chr 2: 216.18 - 216.21 Mb | Chr 1: 71.56 - 71.58 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
ATIC kodira enzim koji generiše inozin monofosfat iz aminoimidazol karboksamid ribonukleotida.
On ima dve funkcije:
Reference
uredi- ↑ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). „The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping”. J Biol Chem 271 (4): 2225–33. DOI:10.1074/jbc.271.4.2225. PMID 8567683.
- ↑ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). „Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase”. J Biochem 122 (2): 309–13. PMID 9378707.
- ↑ „Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase”.
Literatura
uredi- Rasmussen HH, van Damme J, Puype M i dr.. (1993). „Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes”. Electrophoresis 13 (12): 960–9. DOI:10.1002/elps.11501301199. PMID 1286667.
- Yamauchi M, Seki N, Mita K i dr.. (1996). „Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript”. DNA Res. 2 (6): 269–75. DOI:10.1093/dnares/2.6.269. PMID 8867801.
- Beardsley GP, Rayl EA, Gunn K i dr.. (1998). „Structure and functional relationships in human pur H”. Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 431: 221–6. DOI:10.1007/978-1-4615-5381-6_43. ISBN 978-0-306-45778-4. PMID 9598063.
- Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). „Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity”. J. Biol. Chem. 276 (11): 7727–33. DOI:10.1074/jbc.M009940200. PMID 11096114.
- Bulock KG, Beardsley GP, Anderson KS (2002). „The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling”. J. Biol. Chem. 277 (25): 22168–74. DOI:10.1074/jbc.M111964200. PMID 11948179.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cheong CG, Wolan DW, Greasley SE i dr.. (2004). „Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates”. J. Biol. Chem. 279 (17): 18034–45. DOI:10.1074/jbc.M313691200. PMID 14966129.
- Marie S, Heron B, Bitoun P i dr.. (2004). „AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC”. Am. J. Hum. Genet. 74 (6): 1276–81. DOI:10.1086/421475. PMC 1182092. PMID 15114530.
- Dervieux T, Furst D, Lein DO i dr.. (2004). „Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis”. Arthritis Rheum. 50 (9): 2766–74. DOI:10.1002/art.20460. PMID 15457444.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ewing RM, Chu P, Elisma F i dr.. (2007). „Large-scale mapping of human protein–protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931.