Receptor paratiroidnog hormona 2
(Preusmjereno sa stranice PTH2R)
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Parathyroid hormone 2 receptor je protein koji je kod ljudi kodiran PTH2R genom[1]
| Receptor paratiroidnog hormona 2 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | PTH2R; PTHR2 | ||||||||||
| Vanjski ID | OMIM: 601469 MGI: 2180917 HomoloGene: 3701 IUPHAR: PTH2 GeneCards: PTH2R Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5746 | 213527 | |||||||||
| Ensembl | ENSG00000144407 | ENSMUSG00000025946 | |||||||||
| UniProt | P49190 | Q91V95 | |||||||||
| RefSeq (mRNA) | NM_005048.2 | NM_139270.2 | |||||||||
| RefSeq (protein) | NP_005039.1 | NP_644676.1 | |||||||||
| Lokacija (UCSC) | Chr 2: 209.22 - 209.72 Mb | Chr 1: 65.33 - 65.44 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija uredi
Ovaj protein je član familije 2 G protein spregnutih receptora. On je receptor za paratiroidni hormon (PTH). Ovaj receptor je selektiviji u prepoznavanju liganda i ima specifičniju tkivnu distribuciju u poređenju sa receptorom paratiroidnog hormona 2 (PTH1R). On se aktivira samo posredstvom PTH, a ne i PTHLH. on je posebno zastupljen u mozgu i pankreasu.[1]
Reference uredi
Literatura uredi
- Usdin TB, Gruber C, Bonner TI (1995). „Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.”. J. Biol. Chem. 270 (26): 15455–8. DOI:10.1074/jbc.270.26.15455. PMID 7797535.
- Usdin TB, Modi W, Bonner TI (1997). „Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.”. Genomics 37 (1): 140–1. DOI:10.1006/geno.1996.0532. PMID 8921382.
- Clark JA, Bonner TI, Kim AS, Usdin TB (1998). „Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.”. Mol. Endocrinol. 12 (2): 193–206. DOI:10.1210/me.12.2.193. PMID 9482662.
- Hoare SR, Clark JA, Usdin TB (2000). „Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.”. J. Biol. Chem. 275 (35): 27274–83. DOI:10.1074/jbc.M003910200. PMID 10854439.
- John MR, Arai M, Rubin DA, et al. (2002). „Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.”. Endocrinology 143 (3): 1047–57. DOI:10.1210/en.143.3.1047. PMID 11861531.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Seeliger S, Hausberg M, Eue I, et al. (2003). „The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.”. Clin. Nephrol. 59 (6): 429–35. PMID 12834174.
- Bisello A, Manen D, Pierroz DD, et al. (2004). „Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.”. Mol. Endocrinol. 18 (6): 1486–98. DOI:10.1210/me.2003-0487. PMID 14988434.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.”. FEBS Lett. 579 (3): 803–7. DOI:10.1016/j.febslet.2004.12.056. PMID 15670850.
Vidi još uredi
Spoljašnje veze uredi
- „Parathyroid Hormone Receptors: PTH2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
- MeSH Receptor,+Parathyroid+Hormone,+Type+2