Legumain
(Preusmjereno sa stranice PRSC1 gene product (Homo sapiens))
Legumain (EC 3.4.22.34, asparaginska endopeptidaza, citvak, proteinaza B, hemoglobinaza, PRSC1 genski produkt (Homo sapiens), vicilinska peptidohidrolaza, endopeptidaza pasulja, vicilinska peptidohidrolaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Legumain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.34 | ||||||||
| CAS broj | 149371-18-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza proteina i malih molekulskih supstrata na -Asn-Xaa- vezama
Ovaj enzim je prisutan u mahunama metilja Schistosoma mansoni, i u lizozomima sisara.
Reference uredi
- ↑ Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 746-749.
- ↑ Dalton, J.P. and Brindley, P.J. (1998). „Schistosome legumain”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 749-754.
- ↑ Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. (1998). „Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases”. FEBS Lett. 441: 361-365. PMID 9891971.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Dalton, J.P. and Brindley, P.J. (1998). „Schistosome legumain”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 749-754.
- Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 746-749.