Peroksiredoksin
(Preusmjereno sa stranice PRDX)
Peroksiredoksin (EC 1.11.1.15, tioredoksinska peroksidaza, triparedoksinska peroksidaza, alkilna hidroperoksidna reduktaza C22, AhpC, TrxPx, TXNPx, Prx, PRDX) je enzim sa sistematskim imenom tiolni-reduktant:hidroperoksid oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Peroksiredoksin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Triparedoksinska peroksidaza dekamer, Leishmania major | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.11.1.15 | ||||||||
| CAS broj | 207137-51-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 R'-SH + ROOH R'-S-S-R' + H2O + ROH
Peroksiredoksini (Prxs) su sveprisutna familija antioksidansnih proteina. Oni se dele u tri klase: tipični 2-Cys, atipični 2-Cys i 1-Cys peroksiredoksins.
Reference uredi
- ↑ Wood, Z.A., Schröder, E., Harris, J.R. and Poole, L.B. (2003). „Structure, mechanism and regulation of peroxiredoxins”. Trends Biochem. Sci. 28: 32-40. PMID 12517450.
- ↑ Hofmann, B., Hecht, H.J. and Flohé, L. (2002). „Peroxiredoxins”. Biol. Chem. 383: 347-364. PMID 12033427.
- ↑ Seo, M.S., Kang, S.W., Kim, K., Baines, I.C., Lee, T.H. and Rhee, S.G. (2000). „Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate”. J. Biol. Chem. 275: 20346-20354. PMID 10751410.
- ↑ Choi, H.J., Kang, S.W., Yang, C.H., Rhee, S.G. and Ryu, S.E. (1998). „Crystal structure of a novel human peroxidase enzyme at 2.0 Å resolution”. Nat. Struct. Biol. 5: 400-406. PMID 9587003.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.