Fosforibozilantranilatna izomeraza
(Preusmjereno sa stranice PRA isomerase)
Fosforibozilantranilatna izomeraza (EC 5.3.1.24, PRA izomeraza, PRAI, IGPS:PRAI (indol-3-glicerol-fosfat sintetaza/N-5'-fosforibozilantranilat izomeraza kompleks), N-(5-fosfo-beta-D-ribozil)antranilat ketol-izomeraza) je enzim sa sistematskim imenom N-(5-fosfo-beta-D-ribozil)antranilat aldoza-ketoza-izomeraza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosforibozilantranilatna izomeraza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 5.3.1.24 | ||||||||
| CAS broj | 37259-82-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- N-(5-fosfo-beta-D-ribozil)antranilat 1-(2-karboksifenilamino)-1-dezoksi-D-ribuloza 5-fosfat
U pojedinim organizmima ovaj enzim je deo multifunkcionalnog proteina.
Reference uredi
- ↑ Braus, G.H., Luger, K., Paravicini, G., Schmidheini, T., Kirschner, K. and Hütter, R. (1988). „The role of the TRP1 gene in yeast tryptophan biosynthesis”. J. Biol. Chem. 263: 7868-7875. PMID 3286643.
- ↑ Creighton, T.E. and Yanofsky, C. (1970). „Chorismate to tryptophan (Escherichia coli) - anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase”. Methods Enzymol. 17A: 365-380.
- ↑ Hütter, R., Niederberger, P. and DeMoss, J.A. (1986). „Tryptophan synthetic genes in eukaryotic microorganisms”. Annu. Rev. Microbiol. 40: 55-77. PMID 3535653.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.