Fosfinotricin acetiltransferaza
(Preusmjereno sa stranice PPT acetyltransferase)
Fosfinotricin acetiltransferaza (EC 2.3.1.183, PAT, PPT acetiltransferaza, Pt-N-acetiltransferaza, ac-Pt) je enzim sa sistematskim imenom acetil-KoA:fosfinotricin N-acetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfinotricin acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.183 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acetil-KoA + fosfinotricin KoA + N-acetilfosfinotricin
Supstrat, fosfinotricin, se koristi kao neselektivni herbicid i potentni inhibitor enzima EC 6.3.1.2, glutamat---amonijak ligaze, koji je ključni enzim azotnog metabolizma kod biljki.
Reference uredi
- ↑ Botterman, J., Gosselé, V., Thoen, C. and Lauwereys, M. (1991). „Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins”. Gene 102: 33-37. PMID 1864506.
- ↑ Dröge-Laser, W., Siemeling, U., Pühler, A. and Broer, I. (1994). „The metabolites of the herbicide L-phosphinothricin (glufosinate) (identification, stability, and mobility in transgenic, herbicide-resistant, and untransformed plants)”. Plant Physiol. 105: 159-166. PMID 12232195.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.