Difosfoinozitol-pentakisfosfat kinaza
(Preusmjereno sa stranice PPIP5K1)
Difosfoinozitol-pentakisfosfat kinaza (EC 2.7.4.24, PP-IP5 kinaza, difosfoinozitol pentakisfosfatna kinaza, ATP:5-difosfo-1D-mio-inozitol-pentakisfosfat fosfotransferaza, PP-InsP5 kinaza, PPIP5K, PPIP5K1, PPIP5K2, VIP1, VIP2) je enzim sa sistematskim imenom ATP:1D-mio-inozitol-5-difosfat-pentakisfosfat fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Difosfoinozitol-pentakisfosfat kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.4.24 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + 1D-mio-inozitol 5-difosfat pentakisfosfat ADP + 1D-mio-inozitol bisdifosfat tetrakisfosfat (izomerska konfiguracija je nepoznata)
Ovaj enzim se aktivira osmotskim šokom.
Reference
uredi- ↑ Shears, S.B., Ali, N., Craxton, A. and Bembenek, M.E. (1995). „Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo”. J. Biol. Chem. 270: 10489-10497. PMID 7737983.
- ↑ Albert, C., Safrany, S.T., Bembenek, M.E., Reddy, K.M., Reddy, K.K., Falck, J.-R., Bröcker, M., Shears, S.B. and Mayr, G.W. (1997). „Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells”. Biochem. J. 327: 553-560. PMID 9359429.
- ↑ Fridy, P.C., Otto, J.C., Dollins, D.E. and York, J.D. (2007). „Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases”. J. Biol. Chem. 282: 30754-30762. PMID 17690096.
- ↑ Choi, J.H., Williams, J., Cho, J., Falck, J.R. and Shears, S.B. (2007). „Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that Is activated when cells are exposed to hyperosmotic stress”. J. Biol. Chem. 282: 30763-30775. PMID 17702752.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.