Piridoksalna fosfataza
(Preusmjereno sa stranice PNP phosphatase)
Piridoksalna fosfataza (EC 3.1.3.74, vitamin B6 (piridoksin) fosfataza, PLP fosfataza, vitamin B6-fosfatna fosfataza, PNP fosfataza) je enzim sa sistematskim imenom piridoksal-5'-fosfat fosfohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Piridoksalna fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.74 | ||||||||
| CAS broj | 9076-92-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- piridoksal 5'-fosfat + H2O piridoksal + fosfat
Za rad ovog enzim je neophodan Mg2+.
Reference
uredi- ↑ Fonda, M.L. (1992). „Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes”. J. Biol. Chem. 267: 15978-15983. PMID 1322411.
- ↑ Fonda, M.L. and Zhang, Y.N. (1995). „Kinetic mechanism and divalent metal activation of human erythrocyte pyridoxal phosphatase”. Arch. Biochem. Biophys. 320: 345-352. PMID 7625842.
- ↑ Jang, Y.M., Kim, D.W., Kang, T.C., Won, M.H., Baek, N.I., Moon, B.J., Choi, S.Y. and Kwon, O.S. (2003). „Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution”. J. Biol. Chem. 278: 50040-50046. PMID 14522954.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.